Drug interactions
Famotidine + Infigratinib
Severity: Major
Famotidine and Infigratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib absorption depends on gastric acidity, and famotidine raises gastric pH. This can lower infigratinib exposure and reduce its antitumor effect.
What this interaction means in plain words
Famotidine and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Increased gastric pH reduces the pH-dependent solubility and absorption of infigratinib.
What to do
Avoid concurrent H2 antagonists where possible. If unavoidable, give infigratinib 2 hours before or 10 hours after famotidine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Famotidine
- Atazanavir + Famotidine Major
- Dasatinib + Famotidine Major
- Famotidine + Itraconazole Major
- Famotidine + Levoketoconazole Major
- Famotidine + Neratinib Major
- Famotidine + Pazopanib Major
Frequently asked questions
Can I take Famotidine with Infigratinib?
MediHelp rates the interaction as major. Famotidine and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Infigratinib absorption depends on gastric acidity, and famotidine raises gastric pH. This can lower infigratinib exposure and reduce its antitumor effect.
How serious is the interaction between Famotidine and Infigratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent H2 antagonists where possible. If unavoidable, give infigratinib 2 hours before or 10 hours after famotidine.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Itraconazole. The full list is on the Famotidine page.
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