Drug interactions
Famotidine + Itraconazole
Severity: Major
Famotidine and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole capsules need gastric acid for absorption, and famotidine can markedly reduce their bioavailability. Subtherapeutic levels can cause antifungal failure.
What this interaction means in plain words
Famotidine and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Famotidine belongs to Gastrointestinal Tract; Itraconazole belongs to Anti Fungals.
Why it happens
Reduced acid-dependent dissolution and absorption of itraconazole capsules.
What to do
Avoid with capsules, or use the oral solution or SUBA-itraconazole. Monitor itraconazole levels and clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Famotidine
- Atazanavir + Famotidine Major
- Dasatinib + Famotidine Major
- Famotidine + Infigratinib Major
- Famotidine + Levoketoconazole Major
- Famotidine + Neratinib Major
- Famotidine + Pazopanib Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Famotidine with Itraconazole?
MediHelp rates the interaction as major. Famotidine and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole capsules need gastric acid for absorption, and famotidine can markedly reduce their bioavailability. Subtherapeutic levels can cause antifungal failure.
How serious is the interaction between Famotidine and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with capsules, or use the oral solution or SUBA-itraconazole. Monitor itraconazole levels and clinical response.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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