Drug interactions
Fenbufen + Hydrochlorothiazide-valsartan
Severity: Moderate
Fenbufen and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can blunt the antihypertensive effect of valsartan and hydrochlorothiazide. In volume-depleted, elderly or renally impaired patients the combination may cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Fenbufen and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow, sodium excretion and potassium excretion, opposing ARB and diuretic effects.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or stopping the NSAID, and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Fenbufen with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Fenbufen and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can blunt the antihypertensive effect of valsartan and hydrochlorothiazide. In volume-depleted, elderly or renally impaired patients the combination may cause acute kidney injury and hyperkalemia.
How serious is the interaction between Fenbufen and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or stopping the NSAID, and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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