Drug interactions
Fenbufen + Ofloxacin
Severity: Major
Fenbufen and Ofloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen is the NSAID best known for provoking convulsions when combined with quinolones, and reports exist of seizures with this class of combination. The risk is higher with epilepsy, prior CNS disease or renal impairment.
What this interaction means in plain words
Fenbufen and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Fluoroquinolone inhibition of GABA-A receptor binding, markedly potentiated by fenbufen.
What to do
Avoid the combination and use a different NSAID or antibiotic. Stop both drugs if seizures or marked agitation occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Fenbufen with Ofloxacin?
MediHelp rates the interaction as major. Fenbufen and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fenbufen is the NSAID best known for provoking convulsions when combined with quinolones, and reports exist of seizures with this class of combination. The risk is higher with epilepsy, prior CNS disease or renal impairment.
How serious is the interaction between Fenbufen and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a different NSAID or antibiotic. Stop both drugs if seizures or marked agitation occur.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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