Drug interactions
Fenbufen + Paroxetine
Severity: Moderate
Fenbufen and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs impair platelet function and NSAIDs injure gastric mucosa and inhibit platelets. Together they increase the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Fenbufen and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet aggregation (serotonin depletion plus COX inhibition) and NSAID mucosal injury.
What to do
Monitor for signs of GI bleeding and use the lowest effective NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Fenbufen with Paroxetine?
MediHelp rates the interaction as moderate. Fenbufen and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs impair platelet function and NSAIDs injure gastric mucosa and inhibit platelets. Together they increase the risk of gastrointestinal and other bleeding.
How serious is the interaction between Fenbufen and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and use the lowest effective NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in high-risk patients.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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