Drug interactions
Fenbufen + Sacubitril-valsartan
Severity: Moderate
Fenbufen and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen reduce renal prostaglandin synthesis, which can impair renal function and cause potassium retention, and this effect adds to valsartan. They may also blunt the antihypertensive effect and increase acute kidney injury risk, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Fenbufen and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular perfusion and potassium excretion, adding to angiotensin receptor blockade.
What to do
Avoid regular NSAID use where possible; if needed, ensure hydration and monitor renal function, potassium and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Fenbufen with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Fenbufen and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen reduce renal prostaglandin synthesis, which can impair renal function and cause potassium retention, and this effect adds to valsartan. They may also blunt the antihypertensive effect and increase acute kidney injury risk, especially in elderly or volume-depleted patients.
How serious is the interaction between Fenbufen and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible; if needed, ensure hydration and monitor renal function, potassium and blood pressure.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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