Drug interactions
Fenbufen + Valsartan
Severity: Moderate
Fenbufen and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can reduce the antihypertensive effect of valsartan and raise the risk of hyperkalemia. Combined use can also impair renal function, particularly in older patients, those who are volume depleted, or those with existing kidney disease.
What this interaction means in plain words
Fenbufen and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, and combined with ARB blockade of efferent tone this lowers glomerular filtration and raises potassium.
What to do
Monitor blood pressure, serum potassium and creatinine, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Fenbufen with Valsartan?
MediHelp rates the interaction as moderate. Fenbufen and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can reduce the antihypertensive effect of valsartan and raise the risk of hyperkalemia. Combined use can also impair renal function, particularly in older patients, those who are volume depleted, or those with existing kidney disease.
How serious is the interaction between Fenbufen and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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