Drug interactions
Fenofibrate micronized + Fluvastatin
Severity: Moderate
Fenofibrate micronized and Fluvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a fibrate with a statin raises the risk of myopathy and rhabdomyolysis. Fenofibrate carries a lower risk than gemfibrozil because it does not substantially impair statin glucuronidation, and fluvastatin is also less affected by this pathway.
What this interaction means in plain words
Fenofibrate micronized and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic muscle toxicity of both drug classes, without a major pharmacokinetic interaction.
What to do
Use the combination only when the lipid benefit justifies it, starting with low doses. Counsel the patient to report muscle pain or weakness, and measure CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Frequently asked questions
Can I take Fenofibrate micronized with Fluvastatin?
MediHelp rates the interaction as moderate. Fenofibrate micronized and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a fibrate with a statin raises the risk of myopathy and rhabdomyolysis. Fenofibrate carries a lower risk than gemfibrozil because it does not substantially impair statin glucuronidation, and fluvastatin is also less affected by this pathway.
How serious is the interaction between Fenofibrate micronized and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the combination only when the lipid benefit justifies it, starting with low doses. Counsel the patient to report muscle pain or weakness, and measure CK if symptoms occur.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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