Drug interactions
Fenofibrate micronized + Glyburide-metformin
Severity: Minor
Fenofibrate micronized and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate is highly protein bound and could theoretically displace glyburide, but clinically important interactions have not been well established. Fibrates may also improve glycemic control in some patients, which could add slightly to the glucose-lowering effect.
What this interaction means in plain words
Fenofibrate micronized and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible plasma protein binding displacement of glyburide plus a mild additive glucose-lowering effect; evidence is limited.
What to do
Monitor blood glucose when fenofibrate is started. Reduce the glyburide dose only if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenofibrate micronized and Glyburide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Fenofibrate micronized with Glyburide-metformin?
MediHelp rates the interaction as minor. Fenofibrate micronized and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate is highly protein bound and could theoretically displace glyburide, but clinically important interactions have not been well established. Fibrates may also improve glycemic control in some patients, which could add slightly to the glucose-lowering effect.
How serious is the interaction between Fenofibrate micronized and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fenofibrate is started. Reduce the glyburide dose only if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
