Drug interactions
Fenoldopam + Hydralazine
Severity: Moderate
Fenoldopam and Hydralazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoldopam is an intravenous vasodilator used for hypertensive emergencies, so combined use with hydralazine can lead to additive hypotension and reflex tachycardia. Both drugs can also cause headache and flushing.
What this interaction means in plain words
Fenoldopam and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through dopamine D1 receptor agonism and direct arteriolar relaxation.
What to do
Monitor blood pressure continuously during fenoldopam infusion and titrate cautiously. Reduce doses if hypotension or marked tachycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Fenoldopam with Hydralazine?
MediHelp rates the interaction as moderate. Fenoldopam and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoldopam is an intravenous vasodilator used for hypertensive emergencies, so combined use with hydralazine can lead to additive hypotension and reflex tachycardia. Both drugs can also cause headache and flushing.
How serious is the interaction between Fenoldopam and Hydralazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during fenoldopam infusion and titrate cautiously. Reduce doses if hypotension or marked tachycardia develops.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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