Drug interactions
Fenoldopam + Lofexidine
Severity: Moderate
Fenoldopam and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoldopam is a rapid-acting intravenous vasodilator, and lofexidine lowers blood pressure and slows heart rate. Used together, they may cause pronounced hypotension.
What this interaction means in plain words
Fenoldopam and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effect: dopamine D1-mediated vasodilation plus central alpha-2 sympatholysis.
What to do
Monitor blood pressure and heart rate continuously during fenoldopam infusion. Titrate fenoldopam carefully and reduce the dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Fenoldopam with Lofexidine?
MediHelp rates the interaction as moderate. Fenoldopam and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoldopam is a rapid-acting intravenous vasodilator, and lofexidine lowers blood pressure and slows heart rate. Used together, they may cause pronounced hypotension.
How serious is the interaction between Fenoldopam and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during fenoldopam infusion. Titrate fenoldopam carefully and reduce the dose if hypotension develops.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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