Drug interactions
Fenoldopam + Timolol
Severity: Moderate
Fenoldopam and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoldopam is a short-acting vasodilator, and beta-blockers may add to the hypotensive effect. Beta-blockade can also blunt the reflex tachycardia that normally accompanies fenoldopam, leading to greater blood pressure falls.
What this interaction means in plain words
Fenoldopam and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotension: dopamine-1 mediated vasodilation plus beta-blockade, with loss of reflex tachycardia.
What to do
Monitor blood pressure continuously during fenoldopam infusion in patients on timolol, and titrate the infusion to effect. Avoid concurrent beta-blocker bolus dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Fenoldopam with Timolol?
MediHelp rates the interaction as moderate. Fenoldopam and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoldopam is a short-acting vasodilator, and beta-blockers may add to the hypotensive effect. Beta-blockade can also blunt the reflex tachycardia that normally accompanies fenoldopam, leading to greater blood pressure falls.
How serious is the interaction between Fenoldopam and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during fenoldopam infusion in patients on timolol, and titrate the infusion to effect. Avoid concurrent beta-blocker bolus dosing.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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