Drug interactions
Fenoprofen + Fludrocortisone
Severity: Moderate
Fenoprofen and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of GI ulceration and bleeding. Fludrocortisone also causes sodium and fluid retention, which can be worsened by NSAIDs and may raise blood pressure.
What this interaction means in plain words
Fenoprofen and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Fludrocortisone belongs to Endocrine.
Why it happens
Additive GI mucosal injury plus combined sodium and water retention from mineralocorticoid action and NSAID renal prostaglandin inhibition.
What to do
Monitor blood pressure, edema and electrolytes, and consider a proton pump inhibitor if the combination is needed long term. Use the lowest effective NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fenoprofen with Fludrocortisone?
MediHelp rates the interaction as moderate. Fenoprofen and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of GI ulceration and bleeding. Fludrocortisone also causes sodium and fluid retention, which can be worsened by NSAIDs and may raise blood pressure.
How serious is the interaction between Fenoprofen and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and electrolytes, and consider a proton pump inhibitor if the combination is needed long term. Use the lowest effective NSAID dose.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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