Drug interactions
Fenoprofen + Gliclazide
Severity: Moderate
Fenoprofen and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenoprofen can potentiate the glucose-lowering effect of sulfonylureas such as gliclazide. This may produce hypoglycemia, particularly in elderly patients or those with renal impairment.
What this interaction means in plain words
Fenoprofen and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Gliclazide belongs to Endocrine.
Why it happens
Possible displacement of the sulfonylurea from albumin binding and reduced renal prostaglandin-mediated clearance; not firmly established.
What to do
Monitor blood glucose when starting or stopping fenoprofen and counsel the patient on hypoglycemia symptoms. Reduce the gliclazide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Gliclazide?
MediHelp rates the interaction as moderate. Fenoprofen and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenoprofen can potentiate the glucose-lowering effect of sulfonylureas such as gliclazide. This may produce hypoglycemia, particularly in elderly patients or those with renal impairment.
How serious is the interaction between Fenoprofen and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fenoprofen and counsel the patient on hypoglycemia symptoms. Reduce the gliclazide dose if glucose falls.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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