Drug interactions
Fenoprofen + Glipizide-metformin
Severity: Moderate
Fenoprofen and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenoprofen can increase the glucose-lowering effect of sulfonylureas, leading to hypoglycemia in some patients. NSAIDs may also reduce renal function, which raises the risk of metformin accumulation in susceptible patients.
What this interaction means in plain words
Fenoprofen and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Glipizide-metformin belongs to Endocrine.
Why it happens
Possible protein-binding displacement and reduced prostaglandin-mediated renal function, which may impair metformin clearance; the hypoglycemic mechanism is not fully established.
What to do
Monitor blood glucose and renal function when starting or stopping the NSAID, especially in elderly patients or those with renal impairment. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Glipizide-metformin?
MediHelp rates the interaction as moderate. Fenoprofen and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenoprofen can increase the glucose-lowering effect of sulfonylureas, leading to hypoglycemia in some patients. NSAIDs may also reduce renal function, which raises the risk of metformin accumulation in susceptible patients.
How serious is the interaction between Fenoprofen and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when starting or stopping the NSAID, especially in elderly patients or those with renal impairment. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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