Drug interactions
Fenoprofen + Glyburide-metformin
Severity: Moderate
Fenoprofen and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenoprofen may enhance the glucose-lowering effect of sulfonylureas like glyburide, occasionally causing hypoglycemia. NSAIDs can also impair renal function, which may raise metformin exposure in susceptible patients.
What this interaction means in plain words
Fenoprofen and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Glyburide-metformin belongs to Endocrine.
Why it happens
Possible displacement of glyburide from plasma protein binding and reduced renal function from NSAID use, which may increase metformin accumulation.
What to do
Monitor blood glucose when starting or stopping fenoprofen and reduce the glyburide dose if hypoglycemia occurs. Check renal function in patients on long-term NSAID therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Glyburide-metformin?
MediHelp rates the interaction as moderate. Fenoprofen and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenoprofen may enhance the glucose-lowering effect of sulfonylureas like glyburide, occasionally causing hypoglycemia. NSAIDs can also impair renal function, which may raise metformin exposure in susceptible patients.
How serious is the interaction between Fenoprofen and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fenoprofen and reduce the glyburide dose if hypoglycemia occurs. Check renal function in patients on long-term NSAID therapy.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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