Drug interactions
Fenoprofen + Ibrutinib
Severity: Moderate
Fenoprofen and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and is associated with bleeding, and fenoprofen adds antiplatelet and gastrointestinal mucosal-injury effects. Together they raise the risk of clinically significant hemorrhage, including GI bleeding.
What this interaction means in plain words
Fenoprofen and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Ibrutinib belongs to Oncology.
Why it happens
Additive impairment of platelet function (BTK inhibition by ibrutinib, COX-1 inhibition by fenoprofen) plus NSAID gastric mucosal injury.
What to do
Avoid NSAIDs where an alternative analgesic such as paracetamol is suitable. If combined, monitor for bleeding signs and consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Fenoprofen with Ibrutinib?
MediHelp rates the interaction as moderate. Fenoprofen and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and is associated with bleeding, and fenoprofen adds antiplatelet and gastrointestinal mucosal-injury effects. Together they raise the risk of clinically significant hemorrhage, including GI bleeding.
How serious is the interaction between Fenoprofen and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where an alternative analgesic such as paracetamol is suitable. If combined, monitor for bleeding signs and consider gastroprotection.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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