Drug interactions
Fenoprofen + Moexipril
Severity: Moderate
Fenoprofen and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen can reduce the antihypertensive effect of moexipril and may worsen kidney function, particularly in elderly, dehydrated or renally impaired patients. Hyperkalemia risk is also increased.
What this interaction means in plain words
Fenoprofen and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Moexipril belongs to Cardiovascular.
Why it happens
NSAID inhibition of cyclooxygenase reduces renal vasodilatory prostaglandins and sodium excretion, opposing ACE inhibitor effects and lowering glomerular filtration.
What to do
Prefer a non-NSAID analgesic; if the NSAID is needed, ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting and periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Fenoprofen with Moexipril?
MediHelp rates the interaction as moderate. Fenoprofen and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen can reduce the antihypertensive effect of moexipril and may worsen kidney function, particularly in elderly, dehydrated or renally impaired patients. Hyperkalemia risk is also increased.
How serious is the interaction between Fenoprofen and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic; if the NSAID is needed, ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting and periodically.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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