Drug interactions
Fenoprofen + Ofloxacin
Severity: Moderate
Fenoprofen and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the seizure-provoking potential of fluoroquinolones such as ofloxacin. The risk is greatest in patients with epilepsy, CNS disease, renal impairment or older age.
What this interaction means in plain words
Fenoprofen and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones antagonize GABA-A receptors, and NSAIDs may potentiate this effect.
What to do
Avoid the combination in patients with seizure history or other risk factors. Otherwise, monitor for neurological symptoms and consider an alternative analgesic or antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Fenoprofen with Ofloxacin?
MediHelp rates the interaction as moderate. Fenoprofen and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the seizure-provoking potential of fluoroquinolones such as ofloxacin. The risk is greatest in patients with epilepsy, CNS disease, renal impairment or older age.
How serious is the interaction between Fenoprofen and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure history or other risk factors. Otherwise, monitor for neurological symptoms and consider an alternative analgesic or antibiotic.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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