Drug interactions
Fenoprofen + Paroxetine
Severity: Moderate
Fenoprofen and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine depletes platelet serotonin and impairs aggregation, while fenoprofen adds antiplatelet and gastric mucosal-damaging effects. Together they raise the risk of bleeding, notably upper gastrointestinal bleeding.
What this interaction means in plain words
Fenoprofen and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
Additive platelet dysfunction (SSRI serotonin reuptake inhibition in platelets and NSAID COX-1 inhibition) plus NSAID gastric mucosal injury.
What to do
Monitor for signs of GI bleeding and consider a proton pump inhibitor in high-risk patients. Prefer a non-NSAID analgesic such as paracetamol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Fenoprofen with Paroxetine?
MediHelp rates the interaction as moderate. Fenoprofen and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine depletes platelet serotonin and impairs aggregation, while fenoprofen adds antiplatelet and gastric mucosal-damaging effects. Together they raise the risk of bleeding, notably upper gastrointestinal bleeding.
How serious is the interaction between Fenoprofen and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider a proton pump inhibitor in high-risk patients. Prefer a non-NSAID analgesic such as paracetamol where possible.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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