Drug interactions
Fenoprofen + Prednisolone
Severity: Moderate
Fenoprofen and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking a corticosteroid with an NSAID increases the likelihood of peptic ulceration and gastrointestinal bleeding compared with either alone. Risk is higher in older patients and with prolonged use.
What this interaction means in plain words
Fenoprofen and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Prednisolone belongs to Endocrine.
Why it happens
Additive gastrointestinal mucosal injury from prostaglandin inhibition and corticosteroid effects on mucosal protection.
What to do
Use the lowest effective doses for the shortest duration and add a proton pump inhibitor in at-risk patients. Counsel on reporting melena or dyspepsia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Prednisolone?
MediHelp rates the interaction as moderate. Fenoprofen and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking a corticosteroid with an NSAID increases the likelihood of peptic ulceration and gastrointestinal bleeding compared with either alone. Risk is higher in older patients and with prolonged use.
How serious is the interaction between Fenoprofen and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and add a proton pump inhibitor in at-risk patients. Counsel on reporting melena or dyspepsia.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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