Drug interactions
Fenoprofen + Sacubitril-valsartan
Severity: Major
Fenoprofen and Sacubitril-valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin synthesis, which can impair kidney function in patients taking angiotensin receptor blockers, especially the elderly or volume-depleted. They may also blunt the blood pressure and heart failure benefits and increase potassium and fluid retention.
What this interaction means in plain words
Fenoprofen and Sacubitril-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Inhibition of prostaglandin-mediated afferent arteriolar dilation combined with angiotensin receptor blockade reduces glomerular filtration and promotes sodium retention and hyperkalemia.
What to do
Avoid regular NSAID use where possible and use paracetamol or other alternatives. If unavoidable, use the lowest dose for the shortest time and monitor creatinine, potassium and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Sacubitril-valsartan?
MediHelp rates the interaction as major. Fenoprofen and Sacubitril-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs reduce renal prostaglandin synthesis, which can impair kidney function in patients taking angiotensin receptor blockers, especially the elderly or volume-depleted. They may also blunt the blood pressure and heart failure benefits and increase potassium and fluid retention.
How serious is the interaction between Fenoprofen and Sacubitril-valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and use paracetamol or other alternatives. If unavoidable, use the lowest dose for the shortest time and monitor creatinine, potassium and blood pressure.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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