Drug interactions
Fenoprofen + Streptomycin
Severity: Moderate
Fenoprofen and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce aminoglycoside clearance and increase the risk of nephrotoxicity and ototoxicity. The effect has been described mainly in neonates, and fenoprofen may carry a similar risk in renally compromised patients.
What this interaction means in plain words
Fenoprofen and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and glomerular filtration, decreasing aminoglycoside excretion.
What to do
Monitor renal function, hearing and streptomycin levels where available. Avoid the combination in neonates and in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Fenoprofen with Streptomycin?
MediHelp rates the interaction as moderate. Fenoprofen and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce aminoglycoside clearance and increase the risk of nephrotoxicity and ototoxicity. The effect has been described mainly in neonates, and fenoprofen may carry a similar risk in renally compromised patients.
How serious is the interaction between Fenoprofen and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, hearing and streptomycin levels where available. Avoid the combination in neonates and in patients with renal impairment.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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