Drug interactions
Fenoprofen + Tenecteplase
Severity: Major
Fenoprofen and Tenecteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenecteplase is a thrombolytic and fenoprofen impairs platelet function and can injure the gastric mucosa. Together they increase the risk of serious bleeding, including gastrointestinal and intracranial haemorrhage.
What this interaction means in plain words
Fenoprofen and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Tenecteplase belongs to Cardiovascular.
Why it happens
Additive haemostatic impairment: fibrinolysis from tenecteplase combined with reversible NSAID platelet inhibition and mucosal irritation.
What to do
Assess bleeding risk before thrombolysis and avoid starting NSAIDs around the treatment period. Monitor closely for bleeding and neurological change.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Fenoprofen with Tenecteplase?
MediHelp rates the interaction as major. Fenoprofen and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenecteplase is a thrombolytic and fenoprofen impairs platelet function and can injure the gastric mucosa. Together they increase the risk of serious bleeding, including gastrointestinal and intracranial haemorrhage.
How serious is the interaction between Fenoprofen and Tenecteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess bleeding risk before thrombolysis and avoid starting NSAIDs around the treatment period. Monitor closely for bleeding and neurological change.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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