Drug interactions
Dalteparin + Tenecteplase
Severity: Major
Dalteparin and Tenecteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenecteplase is a thrombolytic, and combining it with dalteparin increases the risk of major bleeding including intracranial hemorrhage. Co-administration is used only in specific protocols for acute coronary syndromes or stroke.
What this interaction means in plain words
Dalteparin and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Tenecteplase belongs to Cardiovascular.
Why it happens
Fibrin-specific plasminogen activation combined with factor Xa-mediated anticoagulation yields additive hemorrhagic risk.
What to do
Use only according to a specialist protocol with defined timing of anticoagulation. Monitor closely for bleeding and neurological deterioration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Diclofenac + Tenecteplase Major
Frequently asked questions
Can I take Dalteparin with Tenecteplase?
MediHelp rates the interaction as major. Dalteparin and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenecteplase is a thrombolytic, and combining it with dalteparin increases the risk of major bleeding including intracranial hemorrhage. Co-administration is used only in specific protocols for acute coronary syndromes or stroke.
How serious is the interaction between Dalteparin and Tenecteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only according to a specialist protocol with defined timing of anticoagulation. Monitor closely for bleeding and neurological deterioration.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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