Drug interactions
Fenoprofen + Timolol
Severity: Moderate
Fenoprofen and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sustained NSAID use can reduce the blood pressure lowering effect of oral beta blockers such as timolol. Systemic effects with ophthalmic timolol are smaller.
What this interaction means in plain words
Fenoprofen and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Timolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium and water retention that opposes beta blocker effects.
What to do
Monitor blood pressure during regular fenoprofen use and adjust timolol dosing if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Fenoprofen with Timolol?
MediHelp rates the interaction as moderate. Fenoprofen and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sustained NSAID use can reduce the blood pressure lowering effect of oral beta blockers such as timolol. Systemic effects with ophthalmic timolol are smaller.
How serious is the interaction between Fenoprofen and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during regular fenoprofen use and adjust timolol dosing if control worsens.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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