Drug interactions
Fenoprofen + Tolvaptan
Severity: Minor
Fenoprofen and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no well-established clinically significant interaction between fenoprofen and tolvaptan. Tolvaptan does not typically raise potassium, and NSAID effects on renal function and fluid status are the main general concern.
What this interaction means in plain words
Fenoprofen and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenoprofen belongs to Musculoskeletal; Tolvaptan belongs to Endocrine.
Why it happens
No established interaction mechanism; NSAID-related renal prostaglandin inhibition could theoretically alter fluid and renal responses.
What to do
No specific adjustment is needed; monitor serum sodium and renal function as usual during tolvaptan therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Fenoprofen with Tolvaptan?
MediHelp rates the interaction as minor. Fenoprofen and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no well-established clinically significant interaction between fenoprofen and tolvaptan. Tolvaptan does not typically raise potassium, and NSAID effects on renal function and fluid status are the main general concern.
How serious is the interaction between Fenoprofen and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is needed; monitor serum sodium and renal function as usual during tolvaptan therapy.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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