Drug interactions
Fenoprofen + Triamterene
Severity: Major
Fenoprofen and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with triamterene can cause hyperkalemia and acute kidney injury. Triamterene with NSAIDs has also been associated with reduced renal function, particularly in older or volume-depleted patients.
What this interaction means in plain words
Fenoprofen and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
NSAIDs reduce renal prostaglandin synthesis, lowering renin and aldosterone and renal perfusion, which adds to the potassium-sparing effect of triamterene.
What to do
Avoid the combination where possible, especially in renal impairment or the elderly. If used, monitor serum potassium and creatinine at baseline and regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Fenoprofen with Triamterene?
MediHelp rates the interaction as major. Fenoprofen and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with triamterene can cause hyperkalemia and acute kidney injury. Triamterene with NSAIDs has also been associated with reduced renal function, particularly in older or volume-depleted patients.
How serious is the interaction between Fenoprofen and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially in renal impairment or the elderly. If used, monitor serum potassium and creatinine at baseline and regularly.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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