Drug interactions
Fentanyl + Hydrochlorothiazide-telmisartan
Severity: Minor
Fentanyl and Hydrochlorothiazide-telmisartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl can cause hypotension, and combined with the antihypertensive and volume-depleting effects of hydrochlorothiazide-telmisartan this may increase the risk of low blood pressure and dizziness. Opioid-related antidiuretic effects and urinary retention may also blunt diuretic response.
What this interaction means in plain words
Fentanyl and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects, with opioid-mediated ADH release and urinary retention possibly reducing diuretic efficacy.
What to do
Monitor blood pressure, especially after starting or increasing fentanyl, and check fluid status and urinary output if diuretic effect appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as minor. Fentanyl and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fentanyl can cause hypotension, and combined with the antihypertensive and volume-depleting effects of hydrochlorothiazide-telmisartan this may increase the risk of low blood pressure and dizziness. Opioid-related antidiuretic effects and urinary retention may also blunt diuretic response.
How serious is the interaction between Fentanyl and Hydrochlorothiazide-telmisartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially after starting or increasing fentanyl, and check fluid status and urinary output if diuretic effect appears reduced.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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