Drug interactions
Fentanyl + Hydrochlorothiazide-valsartan
Severity: Moderate
Fentanyl and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl can cause hypotension, and combined with antihypertensives it may lead to a greater drop in blood pressure, especially with orthostatic change. Opioids may also promote antidiuretic hormone release and urinary retention, which could blunt diuretic effect.
What this interaction means in plain words
Fentanyl and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects and opioid-related antidiuretic hormone release and urinary retention opposing diuretic action.
What to do
Monitor blood pressure and volume status, particularly after starting or increasing fentanyl. Rise slowly from lying or sitting and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Fentanyl and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl can cause hypotension, and combined with antihypertensives it may lead to a greater drop in blood pressure, especially with orthostatic change. Opioids may also promote antidiuretic hormone release and urinary retention, which could blunt diuretic effect.
How serious is the interaction between Fentanyl and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status, particularly after starting or increasing fentanyl. Rise slowly from lying or sitting and ensure adequate hydration.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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