Drug interactions
Fentanyl + Istradefylline
Severity: Moderate
Fentanyl and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the higher 40 mg daily dose, istradefylline weakly inhibits CYP3A4 and may raise fentanyl exposure. The effect is likely modest, but opioid effects could be enhanced.
What this interaction means in plain words
Fentanyl and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Istradefylline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by istradefylline reducing fentanyl clearance.
What to do
Monitor for sedation and respiratory depression, and consider a lower fentanyl dose if istradefylline 40 mg daily is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Fentanyl with Istradefylline?
MediHelp rates the interaction as moderate. Fentanyl and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At the higher 40 mg daily dose, istradefylline weakly inhibits CYP3A4 and may raise fentanyl exposure. The effect is likely modest, but opioid effects could be enhanced.
How serious is the interaction between Fentanyl and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, and consider a lower fentanyl dose if istradefylline 40 mg daily is used.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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