Drug interactions
Fentanyl + Ivosidenib
Severity: Moderate
Fentanyl and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may reduce fentanyl concentrations, causing reduced analgesia or withdrawal. When ivosidenib is stopped, fentanyl exposure may rise.
What this interaction means in plain words
Fentanyl and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing fentanyl clearance.
What to do
Monitor pain control and withdrawal signs and titrate fentanyl upward as needed. After stopping ivosidenib, reduce the dose and monitor for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Fentanyl with Ivosidenib?
MediHelp rates the interaction as moderate. Fentanyl and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may reduce fentanyl concentrations, causing reduced analgesia or withdrawal. When ivosidenib is stopped, fentanyl exposure may rise.
How serious is the interaction between Fentanyl and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and withdrawal signs and titrate fentanyl upward as needed. After stopping ivosidenib, reduce the dose and monitor for sedation.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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