Drug interactions
Fentanyl + Lorlatinib
Severity: Moderate
Fentanyl and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4, which may lower fentanyl concentrations and reduce analgesia. When lorlatinib is stopped, fentanyl levels may rise again, leading to excess opioid effect.
What this interaction means in plain words
Fentanyl and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Lorlatinib belongs to Oncology.
Why it happens
Moderate CYP3A4 induction by lorlatinib increases fentanyl metabolism.
What to do
Monitor analgesic response and titrate fentanyl upward as required. After stopping lorlatinib, reassess and reduce the dose to avoid respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Fentanyl with Lorlatinib?
MediHelp rates the interaction as moderate. Fentanyl and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4, which may lower fentanyl concentrations and reduce analgesia. When lorlatinib is stopped, fentanyl levels may rise again, leading to excess opioid effect.
How serious is the interaction between Fentanyl and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and titrate fentanyl upward as required. After stopping lorlatinib, reassess and reduce the dose to avoid respiratory depression.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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