Drug interactions
Fentanyl + Olutasidenib
Severity: Major
Fentanyl and Olutasidenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olutasidenib induces CYP3A4, and fentanyl is cleared mainly through this enzyme. Concurrent use may lower fentanyl concentrations and reduce analgesia. If the inducer is stopped, fentanyl levels may rise again and cause toxicity.
What this interaction means in plain words
Fentanyl and Olutasidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fentanyl belongs to Musculoskeletal; Olutasidenib belongs to Oncology.
Why it happens
Induction of CYP3A4 by olutasidenib increases the metabolism of fentanyl.
What to do
Monitor for loss of analgesic effect and titrate fentanyl as needed. When olutasidenib is discontinued, reduce the fentanyl dose and watch for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Olutasidenib
Frequently asked questions
Can I take Fentanyl with Olutasidenib?
MediHelp rates the interaction as major. Fentanyl and Olutasidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olutasidenib induces CYP3A4, and fentanyl is cleared mainly through this enzyme. Concurrent use may lower fentanyl concentrations and reduce analgesia. If the inducer is stopped, fentanyl levels may rise again and cause toxicity.
How serious is the interaction between Fentanyl and Olutasidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of analgesic effect and titrate fentanyl as needed. When olutasidenib is discontinued, reduce the fentanyl dose and watch for sedation and respiratory depression.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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