Drug interactions
Fentanyl + Pitolisant
Severity: Minor
Fentanyl and Pitolisant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant is a weak CYP3A4 inducer and may slightly lower fentanyl concentrations. The result could be reduced analgesic effect, with levels rising again after pitolisant is stopped.
What this interaction means in plain words
Fentanyl and Pitolisant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Pitolisant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction increases fentanyl metabolism.
What to do
Monitor pain control and adjust the fentanyl dose if analgesia is inadequate. Watch for increased opioid effects if pitolisant is discontinued.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Fentanyl with Pitolisant?
MediHelp rates the interaction as minor. Fentanyl and Pitolisant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pitolisant is a weak CYP3A4 inducer and may slightly lower fentanyl concentrations. The result could be reduced analgesic effect, with levels rising again after pitolisant is stopped.
How serious is the interaction between Fentanyl and Pitolisant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and adjust the fentanyl dose if analgesia is inadequate. Watch for increased opioid effects if pitolisant is discontinued.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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