Drug interactions
Fentanyl + Scopolamine
Severity: Major
Fentanyl and Scopolamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system, and the combination can cause deeper sedation and confusion. Fentanyl also adds respiratory depression, and both can slow gut motility and cause urinary retention.
What this interaction means in plain words
Fentanyl and Scopolamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fentanyl belongs to Musculoskeletal; Scopolamine belongs to Respiratory.
Why it happens
Additive CNS and respiratory depressant effects of an opioid and a centrally acting anticholinergic.
What to do
Use only if alternatives are inadequate, with the lowest effective doses. Monitor sedation and respiratory rate, and watch for constipation and urinary retention.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Scopolamine
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Scopolamine?
MediHelp rates the interaction as major. Fentanyl and Scopolamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents depress the central nervous system, and the combination can cause deeper sedation and confusion. Fentanyl also adds respiratory depression, and both can slow gut motility and cause urinary retention.
How serious is the interaction between Fentanyl and Scopolamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if alternatives are inadequate, with the lowest effective doses. Monitor sedation and respiratory rate, and watch for constipation and urinary retention.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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