Drug interactions
Fentanyl + Sotorasib
Severity: Moderate
Fentanyl and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a CYP3A4 inducer and may reduce fentanyl exposure, leading to weaker pain control. If sotorasib is withdrawn, fentanyl levels could rise and cause toxicity.
What this interaction means in plain words
Fentanyl and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Sotorasib belongs to Oncology.
Why it happens
CYP3A4 induction by sotorasib increases fentanyl metabolism.
What to do
Monitor analgesic response and titrate fentanyl as needed. If sotorasib is stopped, reassess dose and watch for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Fentanyl with Sotorasib?
MediHelp rates the interaction as moderate. Fentanyl and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a CYP3A4 inducer and may reduce fentanyl exposure, leading to weaker pain control. If sotorasib is withdrawn, fentanyl levels could rise and cause toxicity.
How serious is the interaction between Fentanyl and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and titrate fentanyl as needed. If sotorasib is stopped, reassess dose and watch for sedation and respiratory depression.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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