Drug interactions
Fentanyl + Spironolactone
Severity: Minor
Fentanyl and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids may stimulate antidiuretic hormone release and cause urinary retention, which could blunt the diuretic effect of spironolactone. The effect is usually small and clinically variable.
What this interaction means in plain words
Fentanyl and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Spironolactone belongs to Cardiovascular.
Why it happens
Opioid-induced ADH release and urinary retention may partly offset diuretic-induced fluid loss.
What to do
Monitor fluid balance, weight and urine output in patients on both drugs. Adjust the diuretic dose only if diuretic response is clearly reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Fentanyl with Spironolactone?
MediHelp rates the interaction as minor. Fentanyl and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids may stimulate antidiuretic hormone release and cause urinary retention, which could blunt the diuretic effect of spironolactone. The effect is usually small and clinically variable.
How serious is the interaction between Fentanyl and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid balance, weight and urine output in patients on both drugs. Adjust the diuretic dose only if diuretic response is clearly reduced.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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