Drug interactions
Fentanyl intranasal + Rasagiline
Severity: Contraindicated
Fentanyl intranasal and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors have been associated with severe and unpredictable reactions to opioids, including serotonin syndrome and profound CNS or respiratory depression. Fentanyl has weak serotonergic activity.
What this interaction means in plain words
Fentanyl intranasal and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Serotonergic effects of fentanyl combined with MAO inhibition may cause serotonin toxicity, and an additional poorly defined potentiation of opioid effect has been described.
What to do
Avoid fentanyl during and for 14 days after MAO inhibitor therapy. Select a different analgesic with less serotonergic activity if opioids are required.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fentanyl intranasal with Rasagiline?
MediHelp rates the interaction as contraindicated. Fentanyl intranasal and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors have been associated with severe and unpredictable reactions to opioids, including serotonin syndrome and profound CNS or respiratory depression. Fentanyl has weak serotonergic activity.
How serious is the interaction between Fentanyl intranasal and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid fentanyl during and for 14 days after MAO inhibitor therapy. Select a different analgesic with less serotonergic activity if opioids are required.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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