Drug interactions
Fentanyl intranasal + Safinamide
Severity: Contraindicated
Fentanyl intranasal and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl has weak serotonergic activity, and with MAO inhibitors serotonin syndrome and excessive opioid effects have been reported. The combination can lead to agitation, hyperthermia, autonomic instability and respiratory depression.
What this interaction means in plain words
Fentanyl intranasal and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition combined with fentanyl's serotonergic effect increases serotonergic neurotransmission; opioid CNS depression may also be potentiated.
What to do
Avoid use with safinamide; select an opioid with less serotonergic activity if analgesia is needed and monitor closely for serotonin toxicity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Fentanyl intranasal with Safinamide?
MediHelp rates the interaction as contraindicated. Fentanyl intranasal and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fentanyl has weak serotonergic activity, and with MAO inhibitors serotonin syndrome and excessive opioid effects have been reported. The combination can lead to agitation, hyperthermia, autonomic instability and respiratory depression.
How serious is the interaction between Fentanyl intranasal and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use with safinamide; select an opioid with less serotonergic activity if analgesia is needed and monitor closely for serotonin toxicity.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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