Drug interactions
Fentanyl intranasal + Selegiline
Severity: Contraindicated
Fentanyl intranasal and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors have been associated with severe and unpredictable reactions with opioids, including serotonin syndrome and respiratory or CNS depression. Fentanyl labeling advises against use with MAOIs or within 14 days of stopping them.
What this interaction means in plain words
Fentanyl intranasal and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Fentanyl has serotonergic activity that may add to MAO inhibition, with additive CNS and respiratory depression.
What to do
Avoid fentanyl during and for 14 days after an MAOI and use an alternative analgesic. If unavoidable, monitor for serotonin toxicity and respiratory depression.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Fentanyl intranasal with Selegiline?
MediHelp rates the interaction as contraindicated. Fentanyl intranasal and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors have been associated with severe and unpredictable reactions with opioids, including serotonin syndrome and respiratory or CNS depression. Fentanyl labeling advises against use with MAOIs or within 14 days of stopping them.
How serious is the interaction between Fentanyl intranasal and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid fentanyl during and for 14 days after an MAOI and use an alternative analgesic. If unavoidable, monitor for serotonin toxicity and respiratory depression.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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