Drug interactions
Fentanyl transdermal + Isocarboxazid
Severity: Contraindicated
Fentanyl transdermal and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioid use with MAOIs has caused severe reactions, including serotonin syndrome and profound respiratory and CNS depression. Prolonged transdermal exposure makes any reaction harder to reverse.
What this interaction means in plain words
Fentanyl transdermal and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive serotonergic effect with MAO inhibition, plus unpredictable potentiation of opioid effects not fully defined.
What to do
Avoid the combination and for 14 days after stopping the MAOI. Choose an alternative analgesic strategy and monitor for serotonin toxicity and respiratory depression if exposure occurs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Fentanyl transdermal with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Fentanyl transdermal and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioid use with MAOIs has caused severe reactions, including serotonin syndrome and profound respiratory and CNS depression. Prolonged transdermal exposure makes any reaction harder to reverse.
How serious is the interaction between Fentanyl transdermal and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and for 14 days after stopping the MAOI. Choose an alternative analgesic strategy and monitor for serotonin toxicity and respiratory depression if exposure occurs.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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