Drug interactions
Fentanyl transdermal + Spironolactone
Severity: Minor
Fentanyl transdermal and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids may promote antidiuretic hormone release and urinary retention, which could reduce the effectiveness of diuretics. The effect is minor and of uncertain clinical consequence.
What this interaction means in plain words
Fentanyl transdermal and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced antidiuretic hormone release and urinary retention may oppose diuresis.
What to do
Monitor fluid balance, weight and urine output and adjust diuretic dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Fentanyl transdermal with Spironolactone?
MediHelp rates the interaction as minor. Fentanyl transdermal and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids may promote antidiuretic hormone release and urinary retention, which could reduce the effectiveness of diuretics. The effect is minor and of uncertain clinical consequence.
How serious is the interaction between Fentanyl transdermal and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid balance, weight and urine output and adjust diuretic dose if needed.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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