Drug interactions
Fentanyl transmucosal + Rocuronium
Severity: Moderate
Fentanyl transmucosal and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transmucosal fentanyl is absorbed quickly and may add respiratory depression and sedation to rocuronium paralysis. The concern is greatest where ventilation is not controlled or neuromuscular recovery is incomplete.
What this interaction means in plain words
Fentanyl transmucosal and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive respiratory compromise from central opioid depression and peripheral neuromuscular blockade.
What to do
Ensure airway and ventilatory support and monitor oxygen saturation and train-of-four. Lower opioid doses where ventilation is not controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rocuronium
Frequently asked questions
Can I take Fentanyl transmucosal with Rocuronium?
MediHelp rates the interaction as moderate. Fentanyl transmucosal and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transmucosal fentanyl is absorbed quickly and may add respiratory depression and sedation to rocuronium paralysis. The concern is greatest where ventilation is not controlled or neuromuscular recovery is incomplete.
How serious is the interaction between Fentanyl transmucosal and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure airway and ventilatory support and monitor oxygen saturation and train-of-four. Lower opioid doses where ventilation is not controlled.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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