Drug interactions
Fesoterodine + Glycopyrronium tosylate
Severity: Moderate
Fesoterodine and Glycopyrronium tosylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium has some systemic absorption and can add to the anticholinergic effects of fesoterodine, such as dry mouth, constipation, urinary retention, and blurred vision. The risk is greater with larger application areas and in elderly patients.
What this interaction means in plain words
Fesoterodine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antagonism at muscarinic receptors.
What to do
Monitor for systemic anticholinergic effects, including urinary retention and constipation. Stop one agent if significant effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Glycopyrronium tosylate?
MediHelp rates the interaction as moderate. Fesoterodine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical glycopyrronium has some systemic absorption and can add to the anticholinergic effects of fesoterodine, such as dry mouth, constipation, urinary retention, and blurred vision. The risk is greater with larger application areas and in elderly patients.
How serious is the interaction between Fesoterodine and Glycopyrronium tosylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic anticholinergic effects, including urinary retention and constipation. Stop one agent if significant effects occur.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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