Drug interactions
Fesoterodine + Henbane
Severity: Moderate
Fesoterodine and Henbane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids. Combined with fesoterodine this causes additive anticholinergic effects such as dry mouth, constipation, urinary retention, confusion and tachycardia.
What this interaction means in plain words
Fesoterodine and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism from plant-derived tropane alkaloids.
What to do
Avoid concurrent use of henbane products with fesoterodine, and monitor for anticholinergic toxicity if exposure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fesoterodine and Henbane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Henbane?
MediHelp rates the interaction as moderate. Fesoterodine and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids. Combined with fesoterodine this causes additive anticholinergic effects such as dry mouth, constipation, urinary retention, confusion and tachycardia.
How serious is the interaction between Fesoterodine and Henbane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of henbane products with fesoterodine, and monitor for anticholinergic toxicity if exposure occurs.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
