Drug interactions
Fesoterodine + Homatropine
Severity: Moderate
Fesoterodine and Homatropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Homatropine is an antimuscarinic, and systemic exposure (for example from oral cough combinations) adds to fesoterodine effects. Dry mouth, constipation, urinary retention and blurred vision may be more pronounced.
What this interaction means in plain words
Fesoterodine and Homatropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Homatropine belongs to Genitourinary.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic adverse effects and avoid use in patients with urinary retention or narrow-angle glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Homatropine
- Amantadine + Homatropine Moderate
- Amitriptyline + Homatropine Moderate
- Atropine + Homatropine Moderate
- Benztropine + Homatropine Moderate
- Bethanechol + Homatropine Moderate
- Chlorpromazine + Homatropine Moderate
Frequently asked questions
Can I take Fesoterodine with Homatropine?
MediHelp rates the interaction as moderate. Fesoterodine and Homatropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Homatropine is an antimuscarinic, and systemic exposure (for example from oral cough combinations) adds to fesoterodine effects. Dry mouth, constipation, urinary retention and blurred vision may be more pronounced.
How serious is the interaction between Fesoterodine and Homatropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and avoid use in patients with urinary retention or narrow-angle glaucoma.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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