Drug interactions
Fesoterodine + Lofepramine
Severity: Moderate
Fesoterodine and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with anticholinergic properties, and combining it with fesoterodine adds to antimuscarinic burden. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion, especially in older patients.
What this interaction means in plain words
Fesoterodine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic (anticholinergic) pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects such as urinary retention, constipation and cognitive changes. Consider a lower dose or a less anticholinergic antidepressant in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Lofepramine?
MediHelp rates the interaction as moderate. Fesoterodine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with anticholinergic properties, and combining it with fesoterodine adds to antimuscarinic burden. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion, especially in older patients.
How serious is the interaction between Fesoterodine and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as urinary retention, constipation and cognitive changes. Consider a lower dose or a less anticholinergic antidepressant in elderly patients.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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