Drug interactions
Fesoterodine + Loxapine inhaled
Severity: Moderate
Fesoterodine and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has antimuscarinic activity, so combining it with fesoterodine may intensify anticholinergic effects such as dry mouth, constipation, and urinary retention. The clinical effect is generally modest with single inhaled doses.
What this interaction means in plain words
Fesoterodine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects, particularly urinary retention and constipation, after loxapine dosing. Reassess the need for both agents if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Loxapine inhaled?
MediHelp rates the interaction as moderate. Fesoterodine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has antimuscarinic activity, so combining it with fesoterodine may intensify anticholinergic effects such as dry mouth, constipation, and urinary retention. The clinical effect is generally modest with single inhaled doses.
How serious is the interaction between Fesoterodine and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, particularly urinary retention and constipation, after loxapine dosing. Reassess the need for both agents if symptoms emerge.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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