Drug interactions
Fesoterodine + Lumefantrine
Severity: Minor
Fesoterodine and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6 and could raise exposure to the active metabolite of fesoterodine, 5-hydroxymethyl tolterodine, which is partly cleared by CYP2D6. The clinical effect is likely small, and a short antimalarial course limits exposure.
What this interaction means in plain words
Fesoterodine and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP2D6 inhibition by lumefantrine may reduce clearance of the active metabolite of fesoterodine.
What to do
No dose change is usually needed; monitor for increased anticholinergic effects during the antimalarial course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Lumefantrine?
MediHelp rates the interaction as minor. Fesoterodine and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine inhibits CYP2D6 and could raise exposure to the active metabolite of fesoterodine, 5-hydroxymethyl tolterodine, which is partly cleared by CYP2D6. The clinical effect is likely small, and a short antimalarial course limits exposure.
How serious is the interaction between Fesoterodine and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for increased anticholinergic effects during the antimalarial course.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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